The complement system is part of innate immunity — a cascade of proteins that punches holes in cells marked for destruction. In a handful of rare diseases it turns on the body's own red blood cells, nerves or kidneys. Complement inhibitors block the cascade at C5, before the damaging final step. They are transformative in these conditions, and they raise the risk of meningococcal infection, so vaccination beforehand is mandatory.
The facts on this page are pulled directly from official U.S. FDA datasets — they are not written from memory. Each field below names the dataset it came from, so you can check it yourself.
Plain-English summaries and drug-class explainers are written and reviewed by the Priya Life Science editorial team, led by Sreepriya Prasannan (MSc Digital Transformation of Life Sciences (Innopharma Education / Griffith College); MSc & BSc Botany). Data is retrieved automatically from the sources above and cross-checked with AI-assisted verification (Anthropic's Claude) — brand and generic names are matched against the exact FDA product record so that a combination product or a different formulation cannot be mistaken for the drug on this page. An editor reviews the result before publication. We describe this in full in our editorial standards and corrections policy. The FDA data on this page was last retrieved on 6 Aug 2026.